Bodys endocannabinoid system appears to be new target for drug development against

first_imgSource: Mary Ann Liebert, Inc./Genetic Engineering NewsJournal reference:Kayser, R R. et al. (2019) The Endocannabinoid System: A New Treatment Target for Obsessive Compulsive Disorder?. Cannabis and Cannabinoid Research. doi.org/10.1089/can.2018.0049. Reviewed by James Ives, M.Psych. (Editor)Jun 3 2019The body’s endocannabinoid system, due to the critical role it plays in regulating neurotransmitter signaling, is an enticing target for drug development against disorders associated with anxiety, stress, and repetitive behaviors, such as obsessive-compulsive disorder (OCD). A comprehensive new review article that provides an overview of this complex system, endogenous and exogenous cannabinoids, results of animal studies and human trials to date, and recommendations for future directions is published in Cannabis and Cannabinoid Research, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. Click here to read the full-text article free on the Cannabis and Cannabinoid Research website through June 30, 2019.The article entitled “The Endocannabinoid System: A New Treatment Target for Obsessive Compulsive Disorder?” was coauthored by Reilly Kayser, MD, Ivar Snorrasson, PhD, Margaret Haney, PhD, and H. Blair Simpson, MD, PhD, Columbia University Vagelos College of Physicians and Surgeons, and Francis Lee, MD, PhD, Weill Cornell Medical College, (New York, NY). The researchers present the evidence that links the endocannabinoid system to the pathology underlying OCD. They also explore the potential for targeting this system to relieve symptoms of OCD and related disorders such as anxiety, tic, and impulse control disorders. The review includes and extensive overview of cannabinoids made by the body, and exogenous cannabinoids, including phytocannabinoids found in the marijuana plant and purified and synthetic cannabinoids.Based on both animal study data showing anti-anxiety and anti-compulsive effects of cannabinoid agents and on preliminary human clinical trial data, the authors suggest that continued pharmaceutical development is warranted. Which cannabinoid agents to test and how to measure their effects will be among the important questions to consider in designing future studies. Is there a place for cannabinoid-based medicines in psychiatry? Evidence from animal and human studies points to the endocannabinoid system as an important regulator of emotionality, but how can we exploit this knowledge for therapy? This review article offers a critical assessment of the evidence, focused on obsessive compulsive disorder, and clues to future research.”Daniele Piomelli, PhD, Editor-in-Chief, University of California-Irvine, School of Medicinelast_img read more

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Govt forms Jal Shakti Ministry by merging Water Resources and Drinking Water

first_imgGajendra Singh Shekhawat takes charge as the Minister of Jal Shakti, in New Delhi, on Friday, May 31, 2019.   –  PTI COMMENT ministers (government) A new ‘Jal Shakti’ Ministry, in which the erstwhile ministries of Water Resources and Drinking Water and Sanitation will be merged, has been formed with Gajendra Singh Shekhawat at its helm.Shekhawat took charge of the ministry on Friday, a day after he was sworn in as minister. During the election campaign, Modi had promised to form an integrated ministry dealing with water issues.“All the water related works will be merged under one ministry,” Shekhawat said after taking the charge.The ambit of the Ministry will encompass issues ranging from international and inter-states water disputes, the Namami Gange project, the flagship initiative to clean the Ganges, its tributaries and sub-tributaries and provide clean drinking water.In the first Modi government, the project to clean the Ganga was moved from the Ministry of Environment and Forests to the Ministry of Water Resources. With a greater push and much larger monetary allocation, the Namami Gange project was launched.The Minister said as promised in the party manifesto, the priority will be to provide clean drinking water to everyone.Rebutting the charge that nothing was done under the Namami Gange project, Shekhawat said the Ganga river has been cleaned to a large extent and now the priority will be to clean its tributaries and sub-tributaries.Rattan Lal Kataria will be the Minister of State in the newly formed ministry. May 31, 2019 SHARE SHARE EMAILcenter_img water COMMENTS SHARE Published onlast_img read more

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Farmer at the centre of Maharashtra additional BudgetFarmer at the centre of

first_img COMMENT June 18, 2019 SHARE SHARE EMAIL State Budget Published on SHAREcenter_img COMMENTS Maharashtra Finance Minister Sudhir Mungantiwar on Tuesday presented the additional Budget for 2019-20 with a pro-farmer tilt. The State government has decided to expand the scope of existing accident insurance to cover about 5.5 crore family members of farmers in the State.This is the last Budget of the Devendra Fadnavis government before the Maharashtra Assembly elections. The Finance Minister provided a budgetary outlay of ₹210 crore, which takes care of the premium cost of the insurance scheme in the new avatar. The existing insurance scheme named after late Gopinathji Munde gives insurance cover of up to ₹2 lakh to farmers whose names are in the 7/12 revenue land record extract. The premium for the scheme is paid by the State government.Mungantiwar in his Budget speech also announced that in order to give farmers direct access to markets for their agricultural produce and make available all necessary infrastructure facilities in the value chain, the State of Maharashtra Agribusiness and Rural Transformation (SMART) will be implemented with the help of World Bank. The project aims to create value chain for various crops by directly connecting farmers’ companies to the purchasing companies. This project will approximately cost ₹2,220 crore.Farm sectorKeeping in view the farm sector distress in Maharashtra since 2016 and the pitched battles faced by Fadnavis government over farm loan waiver, the Finance Minister said that at present ₹24,102 crore has been sanctioned to 50.27 lakh account holders under the Chhatrapati Shivaji Maharaj Shetkari SanmanYojana, the farm loan waiver scheme.The Government is going to take a decision shortly to give the benefit of this scheme to those farmers who have become ineligible for technical or other reason. The Government is committed to making farmers debt-free and in any case there will not be any shortage of funds for this scheme till the last eligible farmer becomes debt-free, he said.The Budget, which has been presented three months before State Assembly elections, has focussed on agriculture, irrigation and infrastructure. Irrigation sectorIt proposes ₹12,000 crore for the irrigation sector, ₹350 crore for micro-irrigation and ₹600 crore for research and development by four agricultural universities. Mungantiwar also announced that the State government’s debt has reached ₹4,14,411 crore, but given the size of the state’s economy, the debt could be serviced.MSME sectorThe Maharashtra government desires to create maximum employment through the MSME sector. Under a new scheme, industrial parks will be created at each taluka level for MSMEs . As a pilot project, it is proposed to create such parks in 50 talukas initially. Out of the total plots developed under this scheme, 30 per cent will be reserved for women entrepreneurs. For 2019-20, an outlay of ₹300 crore will be reserved for this scheme, he said. There is no new tax in the Budget, but some aspects of value added tax have been tinkered with, which will give some relief to taxpayers in terms of interest and late fees. Maharashtra Finance Minister Sudhir Mungantiwar (left) and Minister of State Deepak Kesarkar arriving to present the Budget at the monsoon session of the Assembly   –  Vivek Bendre Maharashtralast_img read more

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Kamal Nath govt would even transfer land sky BJP on transfer of

first_img Asian News International BhopalJuly 13, 2019UPDATED: July 13, 2019 12:22 IST Three sniffers, one each from Chhindwara, Satna and Betul have been shifted to CM Kamal Nath’s house in Bhopal. (File photo: PTI)In a move that has invoked sharp criticism from Bharatiya Janata Party (BJP) leaders, the Congress-led Madhya Pradesh government has issued an order transferring 46 police dog handlers across the state along with their canines.According to the order, handlers of tracker, sniffer and narco dogs from 23 Battalion Dog Squad have been given new postings in different districts of the state and have been ordered to rejoin immediately along with their dogs.In the latest postings, three sniffers, one each from Chhindwara, Satna and Betul have been shifted to Chief Minister Kamal Nath’s house in Bhopal.The latest step of transferring the dog-squad has drawn scathing criticism from rival BJP which is using the opportunity to attack the government.Taking a dig at the MP government, the BJP’s state vice president Vijesh Lunawat tweeted, “The Great Kamal Nath government did not spare even dogs from the transfer business. Dog squad transferred in Madhya Pradesh.”BJP MLA Rameshwar Sharma invoked the issue of transfer of dogs to allege that the Congress government would even sell land and sky if they could.”Congress government should have at least left the dogs. The police department has transferred dogs en masse. If it was possible for Kamal Nath government and someone was ready to pay the price, they would even transfer land and sky,” Sharma said in a tweet in Hindi.On Friday, the BJP cornered the Madhya Pradesh government for erroneously issuing transfer order of a ‘Sarpanch’ instead of Panchayat Secretary.Referring to a July 5 order of Rewa District Panchayat, Devtalab MLA Girish Gautam said that instead of transferring Rewa district panchayat Shivpura’s in-charge Vibha Dwivedi, Sarpanch Bihari Lal Patel was transferred.”The minister has become so busy that he has transferred a Sarpanch instead of Panchayat Secretary,” he said.It may be noted that a Sarpanch is elected by people and is not entitled to be transferred by the state government.The BJP has in the past alleged that a “transfer racket” was flourishing in the government under Chief Minister Kamal Nath.”A transfer racket is flourishing in the Congress government under Kamal Nath and officials are at the centre of it. They are engaged in seat sale. Officials bid for seats. Congress is not running a government but a ‘hawala udyog’,” the BJP MLA from Narela Vishwas Sarang had alleged in June this year.READ | Mumbai Police officer saves dog from drowning during floods. Big salute, says InternetALSO READ | In one tweet, Rahul Gandhi mocks Indian Army, Yoga Day, dogsALSO WATCH | Rajnath Singh, Amit Shah slam Rahul Gandhi for mocking Yoga DayFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byKritika Bansal Tags :Follow Dog SquadFollow Madhya Pradesh Kamal Nath govt would even transfer land & sky: BJP on transfer of police dogs, handlers in MPThe Congress government’s latest move of transferring the dog-squad has drawn scathing criticism from BJP which is using the opportunity to attack the Kamal Nath government in Madhy Pradesh.advertisement Nextlast_img read more

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